When high therapeutic doses are used progress should be followed with frequent blood calcium determinations. IN VITAMIN D RESISTANT RICKETS THE RANGE BETWEEN THERAPEUTIC AND TOXIC DOSES IS NARROW. Dosage levels must be individualized and great care exercised to prevent serious toxic effects. Therapeutic dosage should be readjusted as soon as there is clinical improvement. In Vitamin D resistant rickets the range between therapeutic and toxic doses is narrow.Vitamin D administration from fortified foods, dietarysupplements, self-administered and prescription drug sources should be evaluated. In these cases Vitamin D must be strictly restricted. Hypersensitivity to Vitamin D may be one etiologic factor in infants with idiopathic hypercalcemia.
Vitamin D metabolites also mobilize calcium and phosphate from bone and probably increase the reabsorption of calcium and perhaps also of phosphate by the renal tubules.Įrgocalciferol is contraindicated in patients with hypercalcemia, malabsorption syndrome, abnormal sensitivity to the toxic effects of Vitamin D, and hypervitaminosis D. Synthesis of the major biologically active metabolites of Vitamin D occurs in the liver and kidneys and they promote the active absorption of calcium and phosphorus by the small intestine, thus elevating serum calcium and phosphate levels sufficiently to permit bone mineralization.
It is a synthetic calcium regulator and is indicated for use in the treatment of hypoparathyroidism, refractory rickets, also known as Vitamin D resistant rickets and familial hypophosphatemia.
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